Date: Thu, 17 Sep 2009 09:49:13 -0400
Reply-To: joey m <sasuser.joey.m@GMAIL.COM>
Sender: "SAS(r) Discussion" <SAS-L@LISTSERV.UGA.EDU>
From: joey m <sasuser.joey.m@GMAIL.COM>
Subject: Re: Draize scoring
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Paul, Steve, thanks a lot for your comments.
In the past I had used Glimmix with categorical events; in other problems
with scoring (say, 1-to-5 scale, with 0.25 intervals) I used Mixed; but in
those cases I had a lot of observations (hundred of thousands). The
scoring with 1-5 scale had a normal distribution.
I was thinking (after reading an example in Cody's Applied statistical
analysis...) in using Wilcoxon, and doing the analysis at each time point. I
know it sounds very nasty, but in addition to the small datset, the repeated
measures add another complication.
I will try to simulate a dataset (o better try to get a real example) and
see how it works using Wilcoxon and Glimmix.
I will update my novice advances on this matter... : )
I realy appreciate the time you have taken to answer my posting.
On Wed, Sep 16, 2009 at 5:55 PM, Swank, Paul R <Paul.R.Swank@uth.tmc.edu>wrote:
> -----Original Message-----
> From: SAS(r) Discussion [mailto:SAS-L@LISTSERV.UGA.EDU] On Behalf Of joey
> Sent: Tuesday, September 08, 2009 9:52 AM
> To: SAS-L@LISTSERV.UGA.EDU
> Subject: Draize scoring
> Hi all:
> Does someone know a paper (or any SAS reference) to check how to fit a
> non-parametric analysis for Draize Scoring (a subjective evaluation of
> irritation; i.e. edema, erithema, etc; scale goes from 0 to 4; being 0 no
> response, and 4 severe response; all scored at several time points on the
> same animals). I would like to compare several groups against a control at
> each time point.
> I believe a Wilcoxon test must do, but I will appreciate any suggestions.
> Nice day to all,