Date:         Wed, 11 Oct 2006 15:33:23 -0400
Reply-To:     CHKim@BETHESDA.MED.NAVY.MIL
Sender:       "SAS(r) Discussion" <SAS-L@LISTSERV.UGA.EDU>
From:         Cecilia Kim <CHKim@BETHESDA.MED.NAVY.MIL>
Subject:      Re: Non-inferiority analysis
Comments: To: robert.shaw@VA.GOV
Content-Type: text/plain

Robert,


SAS customer support tells me that SAS doesn't do non-inferiority testing.
Check out the link below for more information on Proc power.  This might
help.  Good luck!

http://support.sas.com/faq/003/FAQ00352.html


Cecilia H. Kim, MPH
Nurse Researcher
Comprehensive Colon Cancer Center Initiative
National Naval Medical Center
8901 Wisconsin Avenue
Bethesda, MD 20889
Office (301) 319-5015
PIN 1063751

-----Original Message-----
From: SAS(r) Discussion [mailto:SAS-L@LISTSERV.UGA.EDU] On Behalf Of BobS
Sent: Wednesday, October 11, 2006 2:47 PM
To: SAS-L@LISTSERV.UGA.EDU
Subject: Non-inferiority analysis

Hello group,

My question is how to perform a non-inferiority analysis with SAS.
Which PROC statements should be use? Is this completed in one step or
are there several steps in this study design.

The study is an observational cohort and the methods will be something
like this: Our hypothesis is that Drug X 5mg is non-inferior
(one-sided) to the same Drug X 10mg, evaluating percent lowering of
cholesterol from baseline at 3 months. The cost is almost twice for
10mg than 5mg.

Literature states that Drug X 10mg lower cholesterol 15% from baseline.
We feel that if Drug X 5mg lowers cholesterol by 12% this would
clinically be non-inferior to the 10mg strength and thus not worth the
additional extra cost. There will also be 4-5 covariates to control for
potential bias.

Any help would be appreciated. I have search the SAS database and
internet without success.

BobS
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